Description
Glivec 400 mg tablet (imatinib mesylate) is a targeted cancer therapy that treats blood and stomach cancers. It works by inhibiting specific enzymes that cause cancer cells to multiply. It is highly effective for conditions like Chronic Myeloid Leukemia (CML) and Gastrointestinal Stromal Tumors (GIST). [1, 2, 3]
Key Details
- Active Ingredient: 400 mg of Imatinib (as mesilate). [1]
- Appearance: Very dark yellow to brownish-orange, ovaloid, biconvex tablet with beveled edges. It is debossed with “NVR” on one side and “SL” on the other. [1]
- Mechanism of Action: Targets and blocks tyrosine kinase enzymes (such as the bcr-abl fusion protein) that signal abnormal cells to grow, slowing or stopping cancer progression. [1]
Common Indications
- Chronic Myeloid Leukemia (CML): Used for Philadelphia chromosome-positive CML.
- Acute Lymphoblastic Leukemia (Ph+ ALL): Used in adults in combination with chemotherapy.
- Gastrointestinal Stromal Tumors (GIST): Used for treating certain types of stomach/bowel tumors.
- Other Conditions: Also prescribed for Dermatofibrosarcoma Protuberans (DFSP) and other myelodysplastic/myeloproliferative diseases
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