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Jakavi 5mg tablet

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Description

Jakavi 5mg contains the active ingredient ruxolitinib and belongs to a class of medications called JAK inhibitors. It is primarily used to treat certain bone marrow and blood-related disorders, including intermediate-to-high-risk myelofibrosis, polycythemia vera, and graft-versus-host disease, by blocking specific enzymes that promote abnormal cell growth and inflammation. [1, 2, 3]
Key Details
  • Active Substance: Ruxolitinib (as phosphate) [1]
  • Mechanism of Action: Targets and inhibits Janus Associated Kinases (JAK1 and JAK2). This reduces overactive signaling that causes an enlarged spleen, abnormal blood cell production, and excessive immune activity. [1, 2]
  • Primary Indications:
    • Myelofibrosis: Reduces spleen size and alleviates debilitating symptoms such as fatigue, night sweats, and bone pain.
    • Polycythemia Vera: Manages the condition in patients who are resistant to or cannot tolerate hydroxyurea.
    • Graft-versus-Host Disease (GvHD): Treats both acute and chronic GvHD in adults and children when previous treatments (like corticosteroids) have failed. [1, 2, 3, 4, 5]

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